The formula contains no prostaglandin analogs, no parabens, no harsh preservatives. The safety profile has been validated for use by cancer patients during treatment — that's the most rigorous safety bar I can point to for a cosmetic product. I have recommended it to patients with rosacea, eczema, and periorbital hypersensitivity. Apply it to clean dry skin along the lash line. If you have an active ocular disorder, consult your physician first as a precaution.